Ceralasertib (formate)
Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].
Product Specifications
CAS Number
1352280-98-8
Product Name Alternative
AZD-6738 (formate)
UNSPSC
12352005
Target
ATM/ATR; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ceralasertib-formate.html
Smiles
C[C@H]1N(CCOC1)C2=CC(C3(CC3)[S@@](=N)(C)=O)=NC(C4=C5C(NC=C5)=NC=C4)=N2.OC=O.[F,Cl,Br,I]
Molecular Formula
C20H24N6O2S.xCH2O2
Molecular Weight
458.53
References & Citations
[1]Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6 (42) :44289-305.|[2]Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140 (1) :109-119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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