NEDD4 (M) Antibody, Rabbit Polyclonal
Rabbit polyclonal to NEDD4.Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form ofa thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4 is also involved inthe pathway leading to the degradation of VEGFR-2/KDFR independent of its ubiquitin-ligase activity.NEDD4 can monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization anddegradation in lysosomes. In addition, NEDD4 is part of a signaling complex composed of NEDD4, RAP2A and TNIK, which regulates neuronal dendrite extension and arborization during development.
Product Specifications
Product Name Alternative
UniProt
P46934
Reactivity
Human, Mouse
Immunogen
Middle region of human NEDD4
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Neuroscience
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
149
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Securin-2 (Pituitary Tumor-transforming Gene 2 Protein, PTTG2)
Securin-2 (Pituitary Tumor-transforming Gene 2 Protein, PTTG2)
