TDG (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to TDG.G/T mismatch-specific thymine DNA glycosylase (TDG) belongs to the TDG/mug DNA glycosylasefamily. TDG removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bondbetween the sugar-phosphate backbone of DNA and the mispaired thymine. TDG also removesthymine from C/T and T/T mispairings with lower activity. In addition, TDG can remove uracil and 5-bromouracil from mispairings with guanine. TDG plays a central role in cellular defense againstgenetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.