CD33 (C2) Antibody, Rabbit Polyclonal
Rabbit polyclonal to CD33.Myeloid cell surface antigen CD33 belongs to the immunoglobulin superfamily. It is a putativeadhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding tocells. It preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may bemasked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruitingcytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction throughdephosphorylation of signaling molecules. It induces apoptosis in acute myeloid leukemia.
Product Specifications
Product Name Alternative
UniProt
P20138
Reactivity
Human
Immunogen
C-terminal region of human CD33
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
40
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
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