IDH2 (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to IDH2.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one utilizes NAD (+) as the electron acceptor andthe other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependentwhich localize to the mitochondrial matrix; and two NADP (+) -dependent, one of which is mitochondrialand the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. IDH2 isthe NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria, which plays a role inintermediary metabolism and energy production. IDH2 may tightly associate or interact with thepyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, anddysmorphic features.