DTL (N2) Antibody, Rabbit Polyclonal
Rabbit polyclonal to DTL.Denticleless protein homolog (DTL) belongs to the WD repeat cdt2 family. It is a substrate-specificadapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cyclecontrol, DNA damage response and translesion DNA synthesis. The DCX (DTL) complex, also namedCRL4 (CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 andCDKN1A/p21 (CIP1) . CDT1 degradation in response to DNA damage is necessary to ensure propercell cycle regulation of DNA replication. CDKN1A/p21 (CIP1) degradation during S phase or followingUV irradiation is essential to control replication licensing. In undamaged proliferating cells, theDCX (DTL) complex promotes the 'Lys-164' monoubiquitination of PCNA to regulate PCNA-dependenttranslesion DNA synthesis.
Product Specifications
Product Name Alternative
UniProt
Q9NZJ0
Reactivity
Human
Immunogen
N-terminal region of human DTL
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer, DNA Damage, Epigenetics
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
79
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
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