CBL (N) Antibody, Rabbit Polyclonal
Rabbit polyclonal to CBL.E3 ubiquitin-protein ligase CBL is an adapter protein that functions as a negative regulator of manysignaling pathways that are triggered by activation of cell surface receptors. It acts as an E3 ubiquitinproteinligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and thentransfers it to substrates promoting their degradation by the proteasome. CBL plays an important rolein the regulation of osteoblast differentiation and apoptosis and is essential for osteoclastic boneresorption. Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenilemyelomonocytic leukemia (NSLL) .
Product Specifications
Product Name Alternative
UniProt
P22681
Reactivity
Human
Immunogen
Human CBL protein 34-50aa
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer Biology
Dilution
WB:1:500-1:2000
Purity
Affinity purification
Molecular Weight
Predicted molecular weight: 100 kDa, observed molecular weight: 120 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
1 x PBS (pH 7.4), 100 ug/ml rAlbumin, 40% Glycerol, 0.01% NaN3.
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
