Conophylline
Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].
Product Specifications
CAS Number
142741-24-0
UNSPSC
12352005
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/conophylline.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
CC[C@]1(C2)[C@@]3([H])[C@](C4=CC(O)=C5OC)(CCN3[C@@](C(C=C([C@]6(CCN7C[C@]8([H])[C@@]9([H])O8)[C@]7([H])[C@@]9(C%10)CC)C(NC6=C%10C(OC)=O)=C%11)=C%11O%12)([H])[C@@]%12([H])[C@H]1O)C(NC4=C5OC)=C2C(OC)=O
Molecular Formula
C44H50N4O10
Molecular Weight
794.89
References & Citations
[1]Kojima I, et al. Conophylline: a novel differentiation inducer for pancreatic beta cells. Int J Biochem Cell Biol. 2006;38 (5-6) :923-30.|[2]Kubo N, et al. Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats. Liver Int. 2014 Aug;34 (7) :1057-67.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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