TSC1 (C2) Antibody, Rabbit Polyclonal
Rabbit polyclonal to TSC1.Tuberous sclerosis 1 protein (TSC1) is a peripheral membrane protein. In complex with TSC2, TSC1inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 bynegatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towardsRHEB. It is implicated as a tumor suppressor. TSC1 is involved in microtubule-mediated proteintransport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause oftuberous sclerosis type 1 (TSC1) and may be the cause of focal cortical dysplasia of Taylor ballooncell type (FCDBC) .
Product Specifications
Product Name Alternative
Anti-TSC1 antibody, anti-Hamartin antibody, anti-Tuberous sclerosis 1 protein antibody, anti-KIAA0243 antibody, anti-TSC antibody
UniProt
Q92574
Reactivity
Human
Immunogen
C-terminal region of human TSC1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer Biology
Dilution
WB:1:1000-1:3000
Purity
Affinity purification
Molecular Weight
130
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
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