DKK1 (N) Antibody, Rabbit Polyclonal
Rabbit polyclonal to DKK1.Dickkopf-related protein 1 (DKK1) belongs to the dickkopf family. DKK1 is a secreted protein thatinduces anterior development by antagonizing canonical Wnt signaling upstream of its effect on betacateninregulation. DKK1 inhibits LRP5/6 interaction with Wnt and by forming a ternary complex withthe transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play animportant role in vertebrate development, where they locally inhibit Wnt regulated processes such asantero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Product Specifications
Product Name Alternative
Anti-DKK1 antibody, anti-Dickkopfrelated protein 1 antibody, anti-Dickkopf1 antibody, anti-Dkk1 antibody, anti-hDkk1 antibody, anti-SK antibody
UniProt
O94907
Reactivity
Human
Immunogen
N-terminal region of human DKK1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
27
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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