LAT (C2) Antibody, Rabbit Polyclonal
Rabbit polyclonal to LAT.Linker for activation of T-cells family member 1 (LAT) is a single-pass type III cell membrane protein.LAT is required for TCR (T-cell antigen receptor) -and pre-TCR-mediated signaling, both in mature Tcellsand during their development. LAT is involved in FCGR3 (low affinity immunoglobulin gamma Fcregion receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulinepsilon receptor) -mediated signaling in mast cells. LAT couples activation of these receptors and theirassociated kinases with distal intracellular events, such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruient of PLCG1, GRB2, GRAP2 and other signaling molecules.
Product Specifications
Product Name Alternative
UniProt
O54957
Reactivity
Mouse
Immunogen
C-terminal region of mouse LAT
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics, Immunology
Dilution
WB:1:1000-1:3000
Purity
Affinity purification
Molecular Weight
26
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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