MMS21 (N) Antibody, Rabbit Polyclonal
Rabbit polyclonal to MMS21.MMS21 is also known as E3 SUMO-protein ligase NSE2E3, which is a SUMO-protein ligasecomponent of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks byhomologous recombination. The complex may promote sister chromatid homologous recombinationby recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. MMS21 acts as a E3 ligasemediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesincomponents RAD21 and STAG2. The SUMO protein-ligase activity of MMS21 is required for theprevention of DNA damage-induced apoptosis by facilitating DNA repair.
Product Specifications
Product Name Alternative
UniProt
Q96MF7
Reactivity
Human
Immunogen
N-terminal region of human MMS21
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer, DNA Damage, Epigenetics
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
28
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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