GNE-7915 (tosylate)

GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.

Product Specifications

CAS Number

[2070015-00-6]

UNSPSC

12352005

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gne-7915-tosylate.html

Concentration

10mM

Purity

99.06

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CCNC1=NC(NC2=C(OC)C=C(C(N3CCOCC3)=O)C(F)=C2)=NC=C1C(F)(F)F.CC4=CC=C(S(=O)(O)=O)C=C4

Molecular Formula

C26H29F4N5O6S

Molecular Weight

615.60

References & Citations

[1]Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23 (13) :3690-6.|[2]Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55 (22) :9416-33.