Remodelin (hydrobromide)
Product Specifications
UNSPSC Description
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin hydrobromide inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin hydrobromide inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin hydrobromide enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model[1][2][3][4].
Target Antigen
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Remodelin-hydrobromide.html
Solubility
DMSO : ≥ 44 mg/mL|H2O : < 0.1 mg/mL
Smiles
N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br
Molecular Weight
363.28
References & Citations
[1]Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32. |[2]Ma N, et.al. Inhibition of N-Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication. Int J Mol Sci. 2022 Jun 12;23(12):6573. |[3]Balmus G, et.al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018 Apr 27;9(1):1700. |[4]Zhang X, et.al. N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition. Oxid Med Cell Longev. 2019 Jul 1;2019:7561879. Acta Pharmacol Sin. 2023 Jun 5.|Epigenetics. 2024 Dec;19(1):2417158.|Heliyon. 2023 Jun 8.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Oncogene. 2021 Apr;40(15):2711-2724.|bioRxiv. 2023 Feb 11.|Cell Death Dis. 2023 Nov 1;14(11):712.|Cell Rep. 2023 Jul 17;42(7):112810.|J Agric Food Chem. 2021 Dec 23.|J Virol. 2024 Jan 3:e0135023.|Life Sci. 2023 Jul 17;121948.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16706A/Remodelin-hydrobromide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16706A/Remodelin-hydrobromide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1622921-15-6
Available Sizes
Curated Selection
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