L-736380

L-736380 is a high affinity CCK-B (cholecystokinin B receptor) receptor antagonist, with IC50 values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID50, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED50, 1.7 mg/kg) [1].

Product Specifications

CAS Number

[152885-49-9]

Product Name Alternative

L-736360

UNSPSC

12352005

Target

Cholecystokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-736380.html

Smiles

O=C(N[C@H]1C(N(C2=CC=CC=C2C(C3CCCCC3)=N1)C)=O)NC4=CC=CC(N(C5=NNN=N5)C)=C4

Molecular Formula

C25H29N9O2

Molecular Weight

487.56

References & Citations

[1]J L Castro, et al. Controlled modification of acidity in cholecystokinin B receptor antagonists: N- (1,4-benzodiazepin-3-yl) -N'-[3- (tetrazol-5-ylamino) phenyl]ureas. J Med Chem. 1996 Feb 16;39 (4) :842-9.