CASP10 (M) Antibody, Rabbit Polyclonal

Rabbit polyclonal to CASP10.Caspase 10 (CASP10) belongs to the peptidase C14A family, which is involved in the activationcascade of caspases responsible for apoptosis execution. CASP10 is recruited to both Fas-andTNFR-1 receptors in a FADD dependent manner, and may participate in the granzyme B apoptoticpathways. CASP10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, and hydrolyzes the smallmoleculesubstrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Defects in CASP10 havebeen implicated in autoimmune lymphoproliferative syndrome type 2A (ALPS2A), familial non-Hodgkin lymphoma (NHL) and gastric cancer (GASC) .