RB1 (M) Antibody, Rabbit Polyclonal
Rabbit polyclonal to RB1.Retinoblastoma-associated protein b) is a tumor suppressor and a key regulator of entry into celldivision. RB1 acts as a transcription repressor of E2F1 target genes. The hypophosphorylated, activeform of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest.RB1 is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. When it is time fora cell to enter S phase, complexes of cyclin-dependent kinases (CDK) and cyclins phosphorylate RB1and inhibit its activity.
Product Specifications
Product Name Alternative
Anti-RB1 antibody, anti-Retinoblastomaassociated protein antibody, anti-p105Rb antibody, anti-pRb antibody, anti-pp110 antibody, anti-Rb antibody
UniProt
P06400
Reactivity
Human
Immunogen
Middle region of human RB1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
106
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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