KAISO (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to KAISO.KAISO is also known as Zinc finger and BTB domain-containing protein 33, a transcriptional regulatorwith bimodal DNA-binding specificity. KAISO binds to methylated CpG dinucleotides in theconsensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. KAISO can recruits the N-CoR repressor complex to promote histone deacetylation andthe formation of repressive chromatin structures in target gene promoters. In contrast, KAISO mayalso activate transcription of a subset of target genes by the recruient of CTNND2.