AGER (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to AGER.Advanced glycosylation end product-specific receptor (AGER) is also known as receptor for advancedglycation end products AGE), a member of the immunoglobulin superfamily of cell surfacemolecules. AGER is expressed as full-length, membrane-bound RAGE isoform 1 or as a secretedprotein that lacks a transmembrane domain. The observed M.W. of AGER is 48-58 kD. It is a receptorfor a number of different molecules including the ambloidogenic form of serum amyloid A, amyloidbetaprotein, members of the S100/calgranulin superfamily and advanced glycation end products. Itacts as mediator of both acute and chronic vascular inflammation in conditions such asatherosclerosis and in particular as a complication of diabetes. Alternative splicing yields twotranscript variants encoding different isoforms.