NCOA1 (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to NCOA1.NCOA1 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates thetranscriptional activities in a hormone-dependent fashion. NCOA1 is involved in the coactivation ofvarious nuclear receptors, such as for steroids (PGR, GR and ER), retinoids XRs), thyroid hormone (TRs) and prostanoids (PPARs) . NCOA1 is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. NCOA1 displays histone acetyltransferase activitytoward H3 and H4, and plays a central role in creating multisubunit coactivator complexes that act byboth chromatin remodeling and recruient of general transcription factors.