MLL2 (N) Antibody, Rabbit Polyclonal
Rabbit polyclonal to MLL2.MLL2 is a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) . H3K4merepresents a specific tag for epigenetic transcriptional activation. MLL2 plays a central role in betaglobinlocus transcription regulation by being recruited by NFE2. MLLS acts as a coactivator forestrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also requiredduring the transcriptionally active period of oocyte growth for the establishment and/or maintenance ofbulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption ofmeiosis, oocyte survival and normal zygotic genome activation.
Product Specifications
Product Name Alternative
UniProt
O14686
Reactivity
Human, Mouse
Immunogen
N-terminal region of human MLL2
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
593
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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