MMP13 (M) Antibody, Rabbit Polyclonal

Rabbit polyclonal to MMP13.Matrix metallopeptidase 13 (collagenase 3) (MMP13) is a zinc-dependent endopeptidase that belongsto the matrix metalloproteinase (MMP) family. Members of the MMP family are involved in thebreakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, migration and tissue remodeling. MMP13 has been implicated in disease progressions, including arthritis, chronic ulcers and metastasis. Most MMPs are secreted as zymogens requiringactivation by an extracellular proteinase. MMP13 cleaves type II collagen more efficiently than types Iand III. It may play a role in articular cartilage turnover and cartilage pathophysiology associated withosteoarthritis.