SHH (C1) Antibody, Rabbit Polyclonal

Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC) receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE) .Abberant activation of the SHH signaling pathway is associated with several types of cancer.