FLT3 (C) Antibody, Rabbit Polyclonal
Rabbit polyclonal to FLT3.FMS-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that regulates hematopoiesis.Upon ligand binding, the receptor is activated inducing a homodimer formation in the plasmamembrane leading to autophosphorylation of the receptor. Activated FLT3 can also phosphorylateand activate multiple cytoplasmic effector molecules in pathways implicated in apoptosis, proliferationand differentiation of hematopoietic cells in bone marrow. Mutations that result in constitutiveactivation of this receptor are associated with acute myeloid leukemia and acute lymphoblasticleukemia.
Product Specifications
Product Name Alternative
UniProt
Q00342
Reactivity
Human, Mouse
Immunogen
C-terminal region of mouse FLT3
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
113
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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