CP 154526 (hydrochloride)

CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM) . CP 154526 hydrochloride has anxiolytic activities[1][2].

Product Specifications

CAS Number

[257639-98-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-154526-hydrochloride.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(N2C=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1.Cl

Molecular Formula

C23H33ClN4

Molecular Weight

400.99

Precautions

H302, H315, H319, H335

References & Citations

[1]J Lundkvist, et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol. 1996 Aug 8;309 (2) :195-200.|[2]D W Schulz, et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci U S A. 1996 Sep 17;93 (19) :10477-82.