DNMT1 (C) Antibody, Rabbit Polyclonal
Rabbit polyclonal to DNMT1.DNA (cytosine-5) -methyltransferase 1 (DNMT1) plays a role in methylating CpG residues.Preferentially methylates hemimethylated DNA and regulates tissue-specific patterns of methylatedcytosine residues. During S phase of the cell cycle DNMT1 localizes at replication sites conservingmethylation patterns in the newly synthesized strand, maintaining epigenetic inheritance. During G2and M phases of the cell cycle, DNMT1 associates with chromatin maintaining DNA methylationirrespective of replication. Atypical DNA methylation patterns have been shown to be associated withcertain human tumors and developmental abnormalities.
Product Specifications
Product Name Alternative
UniProt
P26358
Reactivity
Human, Mouse
Immunogen
C-terminal region of human DNMT1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
183
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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