Beta-Catenin1 (C) Antibody, Rabbit Polyclonal
Rabbit polyclonal to Catenin1 beta.beta-catenin1 is a key downstream effector of the Wnt signaling pathway. It is implicated in earlyembryonic development and tumorigenesis. CK1 phosphorylates beta-catenin1 on Ser45, which primesbeta-catenin1 for subsequent phosphorylation by GSK-3 at Ser33, Ser37 and Thr41. Phosphorylation ofbeta-catenin1 by GSK-3beta leads to its degradation. Wnt signaling antagonizes GSK-3b and stablizes bcatenin1.Mutations in these phosphorylation sites, which result in the stabilization of beta-catenin1protein levels, have been found in many tumor cell lines.
Product Specifications
Product Name Alternative
UniProt
P35222
Reactivity
Human, Mouse
Immunogen
C-terminal region of human b-catenin1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics, Infectious Diseases, Neuroscience, Signaling Pathways, Wnt
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
85
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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