M-PEG-NHS ester (MW 2000)

M-PEG-NHS ester (mPEG-SC) is a first-generation PEG reagent. m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects[1][2].

Product Specifications

CAS Number

[92451-01-9]

Product Name Alternative

MPEG-SC (MW 2000) ; mPEG-Succinimidyl ester (MW 2000)

UNSPSC

12352200

Hazard Statement

H302, H315, H319

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/m-peg-nhs-ester-mw-2000.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COCCOCC(ON1C(CCC1=O)=O)=O.[n]

Molecular Formula

(C2H4O) nC7H9NO5

Molecular Weight

2000 (Average)

Precautions

H302, H315, H319

References & Citations

[1]Jin M, et al. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo[J]. Acta Pharmaceutica Sinica B, 2013, 3 (2) : 123-129.|[2]Aghajani-Lazarjani H, et al. The effect of two different polyethylene glycol (PEG) derivatives on the immunological response of PEG grafted pancreatic islets. J Artif Organs. 2010 Dec;13 (4) :218-24.