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BTS

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 μM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers[1][2].

Product Specifications

CAS Number

[1576-37-0]

Product Name Alternative

N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/BTS.html

Purity

99.74

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(NCC1=CC=CC=C1)(C2=CC=C(C)C=C2)=O

Molecular Formula

C14H15NO2S

Molecular Weight

261.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4 (1) :83-8.|[2]Shaw MA, et, al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry. 2003 May 27;42 (20) :6128-35.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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