BTS
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 μM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers[1][2].
Product Specifications
CAS Number
1576-37-0
Product Name Alternative
N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/BTS.html
Purity
99.74
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(NCC1=CC=CC=C1)(C2=CC=C(C)C=C2)=O
Molecular Formula
C14H15NO2S
Molecular Weight
261.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4 (1) :83-8.|[2]Shaw MA, et, al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry. 2003 May 27;42 (20) :6128-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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