HPi1

HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1].

Product Specifications

CAS Number

[13080-21-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hpi1.html

Purity

98.0

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

S=C1NC2=C(C=CC=C2)N=C1NN

Molecular Formula

C8H8N4S

Molecular Weight

192.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58 (6) :3255-60.