TPPU
TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7 nM for monkey and human sEH, respectively.
Product Specifications
CAS Number
1222780-33-7
UNSPSC
12352005
Hazard Statement
H301
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TPPU.html
Purity
99.15
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CC)=O)CC2
Molecular Formula
C16H20F3N3O3
Molecular Weight
359.34
Precautions
H301
References & Citations
[1]Ulu A, et al. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol. 2012 Mar;165 (5) :1401-12.|[2]Ostermann AI, et al. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1- (1-propanoylpiperidin-4-yl) -3-[4- (trifluoromethoxy) phenyl]urea (TPPU) : Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 2015 Sep;121 (Pt A) :131-7.|[3]Ren Q, et al. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America (2016), 113 (13), E1944-E1952.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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