Viloxazine (hydrochloride)
Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD) [1][2][3].
Product Specifications
CAS Number
[35604-67-2]
Product Name Alternative
Viloxazin (hydrochloride) ; Emovit (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/viloxazine-hydrochloride.html
Concentration
10mM
Purity
98.94
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl
Molecular Formula
C13H20ClNO3
Molecular Weight
273.76
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor
Available Sizes
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