MI-1851

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2].

Product Specifications

CAS Number

[2417283-44-2]

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mi-1851.html

Purity

95.92

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC(NCC1=CC=C(C=C1)CC(N[C@H](C(N[C@H](C(N[C@H](C(NCC2=CC=C(C=C2)C(N)=N)=O)CCONC(N)=N)=O)C(C)(C)C)=O)CCONC(N)=N)=O)=N

Molecular Formula

C34H53N15O6

Molecular Weight

767.88

References & Citations

[1] Erzsébet Pászti-Gere, et al. In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity. Biomed Pharmacother. 2022 Jul;151:113124.|[2]Dorothea Bestle, et al. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020 Jul 23;3 (9) :e202000786.|[3]Thuy Van Lam van, et al. The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. ACS Med Chem Lett. 2021 Feb 9;12 (3) :426-432.