Orpinolide
Orpinolide is a withanolide analog that has anti-leukemia properties. It disrupts the internal balance of the Golgi apparatus, which is related to signaling through inositol 4-phosphate at the interface of the endoplasmic reticulum and Golgi membrane[1].
Product Specifications
UNSPSC
12352005
Target
PI4K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/orpinolide.html
Smiles
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)[C@H]5CC(N6CCOCC6)=CC(O5)=O
Molecular Formula
C30H45NO4
Molecular Weight
483.68
References & Citations
[1]Cigler M, et al. Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Nat Chem Biol. 2024 Jun 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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