12-Oxocalanolide A
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC50 and EC50 of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide[1].
Product Specifications
CAS Number
[161753-49-7]
Product Name Alternative
(±) -12-Oxocalanolide A
UNSPSC
12352005
Target
HIV
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/12-oxocalanolide-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C4C(C([C@H](C)[C@@H](C)O4)=O)=C2O1
Molecular Formula
C22H24O5
Molecular Weight
368.42
References & Citations
[1]Zembower DE, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C) . J Med Chem. 1997;40 (6) :1005-1017.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1
Curated Selection
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