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Santacruzamate A

Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research[1][2].

Product Specifications

CAS Number

1477949-42-0

Product Name Alternative

CAY-10683

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; HDAC

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Santacruzamate-A.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OCC)NCCCC(NCCC1=CC=CC=C1)=O

Molecular Formula

C15H22N2O3

Molecular Weight

278.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Pavlik CM, et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76 (11) :2026-33.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

HDAC2; HDAC6

Available Sizes

Frequently Asked Questions

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