Santacruzamate A
Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research[1][2].
Product Specifications
CAS Number
1477949-42-0
Product Name Alternative
CAY-10683
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; HDAC
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Santacruzamate-A.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCC)NCCCC(NCCC1=CC=CC=C1)=O
Molecular Formula
C15H22N2O3
Molecular Weight
278.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Pavlik CM, et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76 (11) :2026-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC2; HDAC6
Available Sizes
Frequently Asked Questions
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