IBMX (Standard)

IBMX (Standard) is the analytical standard of IBMX. This product is intended for research and analytical applications. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.

Product Specifications

CAS Number

[28822-58-4]

Product Name Alternative

3-Isobutyl-1-methylxanthine (Standard) ; Isobutylmethylxanthine (Standard)

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ibmx-standard.html

Purity

99.77

Smiles

O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O

Molecular Formula

C10H14N4O2

Molecular Weight

222.24

References & Citations

[1]Wu BN, et al. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142 (7) :1105-14|[2]Wei Y, et al. Angiotensin II type 2 receptor regulates ROMK-like K+ channel activity in the renal cortical collecting duct during high dietary K+ adaptation. Am J Physiol Renal Physiol. 2014 Oct 1;307 (7) :F833-43|[3]Hosseini A, et al. Differential metabolic effects of novel cilostamide analogs, methyl carbostiryl derivatives, on mouse and hyperglycemic rat. Iran J Basic Med Sci. 2012 Jul;15 (4) :916-25.|[4]Crosswhite P, et al. Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension. Hypertension. 2013 Mar;61 (3) :585-92.