NUCC-390
NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100[2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].
Product Specifications
CAS Number
1060524-97-1
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nucc-390.html
Purity
98.40
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3
Molecular Formula
C23H33N5O
Molecular Weight
395.54
References & Citations
[1]Mishra RK, et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists.Sci Rep. 2016 Jul 26;6:30155.|[2]Negro S, et al. An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals.Cells. 2019 Sep 30;8 (10) . pii: E1183.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4
Citation 01
Arab J Gastroenterol. 2024 Feb;25 (1) :28-36.|Microsc Microanal. 2025 Mar 17;31 (2) :ozaf011.|Proc Natl Acad Sci U S A. 2024 Dec 24;121 (52) :e2416909121.|Int Immunopharmacol. 2024 Nov 30:144:113707.|Neurosci Res. 2023 Jun:191:38-47.
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