Tris[[2- (tert-butoxycarbonyl) ethoxy]methyl]methylamine
Tris[[2- (tert-butoxycarbonyl) ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-Tri- (t-butoxycarbonylethoxymethyl) -methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[175724-30-8]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamine.html
Purity
98.0
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)(N)COCCC(OC(C)(C)C)=O
Molecular Formula
C25H47NO9
Molecular Weight
505.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16 (23) :6912-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
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