CFM-2
CFM-2 is a potent and selective non-competitive AMPAR antagonist[1]. CFM-2 possesses anticonvulsant activity in various models of seizures[2].
Product Specifications
CAS Number
178616-26-7
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/CFM-2.html
Purity
98.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1NN=C(C2=CC=C(N)C=C2)C3=CC(OC)=C(OC)C=C3C1
Molecular Formula
C17H17N3O3
Molecular Weight
311.34
References & Citations
[1]De Sarro G, et al. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368 (2-3) :149-59.|[2]Rizzo M, et al. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731 (2) :207-15.|[3]Stepulak A, et al. AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer Biol Ther. 2007 Dec;6 (12) :1908-15.|[4]Park JS, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008 Dec 30;4:67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
476600 100 µL
C17ORF64 (Uncharacterized Protein C17orf64, Chromosome 17 Open Reading Frame 64)
Sign In for Pricing
View Details 
MBS1017960-01 0.02 mg (E-Coli)
Recombinant Francisella tularensis subsp. tularensis UPF0145 protein FTW_0852 (FTW_0852)
Sign In for Pricing
View Details MBS1017960-02 0.1 mg (E-Coli)
Recombinant Francisella tularensis subsp. tularensis UPF0145 protein FTW_0852 (FTW_0852)
Sign In for Pricing
View Details MBS1017960-03 0.02 mg (Yeast)
Recombinant Francisella tularensis subsp. tularensis UPF0145 protein FTW_0852 (FTW_0852)
Sign In for Pricing
View Details MBS1017960-04 0.1 mg (Yeast)
Recombinant Francisella tularensis subsp. tularensis UPF0145 protein FTW_0852 (FTW_0852)
Sign In for Pricing
View Details MBS1017960-05 0.02 mg (Baculovirus)
Recombinant Francisella tularensis subsp. tularensis UPF0145 protein FTW_0852 (FTW_0852)
Sign In for Pricing
View Details