Saracatinib (difumarate)
Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. [1].
Product Specifications
CAS Number
[893428-72-3]
Product Name Alternative
AZD0530 (difumarate)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/saracatinib-difumarate.html
Purity
99.24
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC1=CC=C2C(OCO2)=C1NC3=C4C(OC5CCOCC5)=CC(OCCN6CCN(C)CC6)=CC4=NC=N3.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O
Molecular Formula
C35H40ClN5O13
Molecular Weight
774.17
Precautions
P261-P280-P302+P352
References & Citations
[1]Green TP, et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol Oncol, 2009, 3 (3), 248-261.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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