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Thalidomide-Piperazine 5-fluoride

Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2222114-22-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-piperazine-5-fluoride.html

Purity

98.02

Solubility

10 mM in DMSO

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(N4CCNCC4)C(F)=C3)=O

Molecular Formula

C17H17FN4O4

Molecular Weight

360.34

Precautions

H315, H319

References & Citations

[1]Hexiang Wang, et al. Degradation of androgen receptor (ar) by conjugation of ar antagonists with e3 ligase ligand and methods of use. WO2021058017A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

Curated Selection

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