DiAzKs

DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe[1][2][3].

Product Specifications

CAS Number

[1253643-88-7]

Product Name Alternative

H-L-Photo-lysine

UNSPSC

12171500

Hazard Statement

H242

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/diazks.html

Purity

99.93

Solubility

DMSO : 2 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

N[C@@H](CCCCNC(OCCC1(C)N=N1)=O)C(O)=O

Molecular Formula

C11H20N4O4

Molecular Weight

272.30

Precautions

H242

References & Citations

[1]Ai HW, et al. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem. 2011 Aug 16;12 (12) :1854-7.|[2]Chatterjee A, et al. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jul 16;110 (29) :11803-8.|[3]Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12 (2) :70-2.