PXB17
PXB17 can inhibit CSF1R (IC50 = 1.7 nM) by blocking the activation of PI3K/ AKT/mTORC1 signaling. PXB17 is orally effective. PXB17 significantly inhibits the growth of CRC, improves PD-1 mAb efficacy and reduces tumor recurrence in CRC[1].
Product Specifications
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pxb17.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C)=C(N1)/C=C2C(NC3=C\2C=CC(NC(NC4=NOC(C(C)(C)C)=C4)=O)=C3)=O)NC(CN5CCCC5)=O
Molecular Formula
C29H35N7O4
Molecular Weight
545.63
References & Citations
[1]Qi L et al. CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer Pharmacological Research 202 (2024) 107126.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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