AChE/BChE-IN-21

AChE/BChE-IN-21 is a histamine H3 receptor antagonist, calcium channel blocker, and acetylcholinesterase inhibitor. AChE/BChE-IN-21 exhibits neuroprotective activity against H2O2 and Aβ1-40, and can restore cognitive function in AD mice[1].

Product Specifications

CAS Number

[2756368-79-1]

UNSPSC

12352005

Target

Amyloid-β; Calcium Channel; Cholinesterase (ChE) ; Histamine Receptor; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-bche-in-21.html

Smiles

O=C(NC(C1=CC=C(OCCCCCN2CCCCC2)C=C1)C(C(OCC)=O)=C3C)N3CCC4CCN(CC4)CC5=CC=CC=C5

Molecular Formula

C38H54N4O4

Molecular Weight

630.86

References & Citations

[1]Malek R, et al. Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors. ACS Chem Neurosci. 2024 Aug 29.