CZC-54252

CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity[1].

Product Specifications

CAS Number

[1191911-27-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CZC-54252.html

Purity

98.05

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O

Molecular Formula

C22H25ClN6O4S

Molecular Weight

504.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6 (10) :1021-8.