AD353
AD353 is a selective sigma-1 receptor ligand with antiallodynic activity. AD353 exhibits high potency both in a model of Capsaicin -induced allodynia and in PGE2-induced mechanical hyperalgesia. AD353 exhibits a favorable pharmacokinetic profile[1].
Product Specifications
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ad353.html
Smiles
O=C(OCC)C(N(C1CCN(CC2=CC=CC=C2)CC1)C)C3=CC=CC=C3
Molecular Formula
C23H30N2O2
Molecular Weight
366.50
References & Citations
[1]Cosentino G, et, al. Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds. Eur J Med Chem. 2025 Jan 5:281:117037.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6454997-01 0.2 mL
CDX4 (Homeobox Protein CDX-4, Caudal-Type Homeobox Protein 4, CDX4) (APC)
Sign In for Pricing
View Details MBS6454997-02 5x 0.2 mL
CDX4 (Homeobox Protein CDX-4, Caudal-Type Homeobox Protein 4, CDX4) (APC)
Sign In for Pricing
View Details 
MBS1444068-01 0.02 mg (E-Coli)
Recombinant Streptomyces coelicolor UPF0157 protein SCO7215 (SCO7215)
Sign In for Pricing
View Details MBS1444068-02 0.1 mg (E-Coli)
Recombinant Streptomyces coelicolor UPF0157 protein SCO7215 (SCO7215)
Sign In for Pricing
View Details MBS1444068-03 0.02 mg (Yeast)
Recombinant Streptomyces coelicolor UPF0157 protein SCO7215 (SCO7215)
Sign In for Pricing
View Details