(R) -Acalabrutinib

(R) -Acalabrutinib ((R) -ACP-196) is the enantiomer of Acalabrutinib (HY-17600) . (R) -Acalabrutinib is an inhibitor for Bruton’s tyrosine kinase (BTK) [1].

Product Specifications

CAS Number

[1952316-43-6]

Product Name Alternative

(R) -ACP-196

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-acalabrutinib.html

Solubility

10 mM in DMSO

Smiles

CC#CC(N1[C@H](CCC1)C2=NC(C3=CC=C(C=C3)C(NC4=CC=CC=N4)=O)=C5N2C=CN=C5N)=O

Molecular Formula

C26H23N7O2

Molecular Weight

465.51

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Rayala VVSPK, et al., A validated chiral chromatographic method for the enantiomeric separation of acalabrutinib. Chirality. 2022 Sep;34 (9) :1247-1256.