Pomalidomide-NH-PEG6-amide-C2-CPI-1612
Pomalidomide-NH-PEG6-amide-C2-CPI-1612 (compound 22 (dCE-1) ) is a CBP/EP300 degrader, which contains a CRBN ligands Pomalidomide, a 24-atom linker with 6 PEG units and a HAT inhibitor CPI-1612. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 exhibits antiproliferative effects in cells multiple myeloma cells LP1 (with a DC50 of 1.2 μM), MM1S and various cancer cell lines, especially the leukemia cells[1].
Product Specifications
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-nh-peg6-amide-c2-cpi-1612.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C(C(N1)=O)CCC1=O)C2=O)C3=C2C(NCCOCCOCCOCCOCCOCCOCCNC(CCCN4N=CC(C5=CC=C(NC([C@@H](C6=CC=CC=C6)NC[C@@H](C)C7=CC=C(C#N)C=C7)=O)N=C5)=C4)=O)=CC=C3
Molecular Formula
C57H68N10O12
Molecular Weight
1085.21
References & Citations
[1]Iván CS, et al., Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain, ACS Med. Chem. Lett.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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